#TB need to be targeted by vaccination

Globally, vaccination with BCG fails to stop spread of Tuberculosis (TB). However, in children BCG can protect against, or at least ameliorate, severe forms of systemic TB, particularly TB meningitis. To interrupt transmission of disease, highly contagious pulmonary forms of TB need to also be targeted by vaccination.

About priMe

In 1993, the World Health Organization (WHO) declared tuberculosis (TB) a global emergency. Approx. 1.7 billion people are infected and 10.4 million people are estimated to fell ill with TB in 2016. In the same year approx. 1.4 million died because of TB; among them 253,000 children (aged 0-14 years). South Africa and other Sub-Saharan countries belong to the group of “high-burden” TB countries with an estimated 97,000 deaths each year in South Africa alone.

In children BCG can protect against, or at least ameliorate, severe forms of systemic TB, particularly TB meningitis.

VPM1002 is an innovative live vaccine against TB, based on the well-known Mycobacterium bovis (M. bovis) Bacille Calmette-Guérin (BCG) strain which has been administered approximately 4 billion times worldwide.

The genetically modifications of VPM1002, namely introduction of listeriolysin while simultaneously deleting the gene for urease C in the BCG genome, are aiming for better recognition by the host immune system.

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