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Centre de Recherches Médicales de Lambaréné

The Centre de Recherches Médicales de Lambaréné (CERMEL), the former "Medical Research Unit of the Albert Schweitzer Hospital”, was established in 1981 as a research centre located in the rain forest region of Gabon in the Central African sub-region. The center has a long history of evaluating interventions against malaria, including phase I to IV drug trials, vaccine candidate evaluations and intermittent preventive treatment in infants and pregnant women. The past years have seen a diversification into other areas such as tuberculosis, as well as bacterial and helminthic infections. A number of epidemiological and social science research projects are performed on a variety of research subjects.

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Max Planck Institute for Infection Biology

The Max Planck Society is Germany's most successful research organization. Since its establishment in 1948, no fewer than 18 Nobel laureates have emerged from the ranks of its scientists, putting it on a par with the best and most prestigious research institutions worldwide. The Department for Immunology, at the Max Planck Institute for Infection Biology in Berlin, is the place of origin of VPM1002. Its Director Stefan H.E. Kaufmann is advising and supporting the further development of their invention and also performing further research into this vaccine and tuberculosis.

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Mecru Clinical Research Unit

Mecru Clinical Research Unit (MeCRU) is a unit which was established at Sefako Makgatho Health Sciences University from October 2005. The facility was established with the support of the Medical Research Council through the South African AIDS Vaccine Initiative (SAAVI) and was officially opened by Minister of Health, Dr Aaron Motsoaledi, on the 3rd of June 2010. It is located at the Sefako Makgatho Health Sciences University (SMU) where there is wide spectrum of qualified specialists in health who have varying degrees of competence in research and clinical work. The SMU is attached to Dr George Mukhari Academic Hospital, a 1400 bed tertiary hospital a tertiary hospital used for the training of health professionals.

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Medical Research Council/Uganda Virus Research Institute

The proposed trial will be conducted within the Entebbe Mother and Baby Study (EMaBS) clinic in collaboration with the Entebbe Hospital located within the same environs. The EMaBS birth cohort was established in 2002 to investigate effects of helminths and their treatment on immune responses to vaccines and on susceptibility to infectious and allergy-related diseases. EMaBS is under the Immunomodulation and Vaccines (IVac) programme of the MRC/UVRI Uganda Research Unit. They have a long-standing interest in improving the understanding BCG immunization in tropical settings and have previously and currently carried out several studies on BCG. These include investigating the impact of maternal worm infections on the infant immune response to BCG (8), and the effects of maternal latent tuberculosis infection on the response to BCG and they have compared the immunogenicity of different BCG strains and examined the non-specific benefits of BCG immunization.

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Centre de Recherches Médicales de Lambaréné

The Centre de Recherches Médicales de Lambaréné (CERMEL), the former "Medical Research Unit of the Albert Schweitzer Hospital”, was established in 1981 as a research centre located in the rain forest region of Gabon in the Central African sub-region. The center has a long history of evaluating interventions against malaria, including phase I to IV drug trials, vaccine candidate evaluations and intermittent preventive treatment in infants and pregnant women. The past years have seen a diversification into other areas such as tuberculosis, as well as bacterial and helminthic infections. A number of epidemiological and social science research projects are performed on a variety of research subjects.

Max Planck Institute for Infection Biology

The Max Planck Society is Germany's most successful research organization. Since its establishment in 1948, no fewer than 18 Nobel laureates have emerged from the ranks of its scientists, putting it on a par with the best and most prestigious research institutions worldwide. The Department for Immunology, at the Max Planck Institute for Infection Biology in Berlin, is the place of origin of VPM1002. Its Director Stefan H.E. Kaufmann is advising and supporting the further development of their invention and also performing further research into this vaccine and tuberculosis.

Mecru Clinical Research Unit

Mecru Clinical Research Unit (MeCRU) is a unit which was established at Sefako Makgatho Health Sciences University from October 2005. The facility was established with the support of the Medical Research Council through the South African AIDS Vaccine Initiative (SAAVI) and was officially opened by Minister of Health, Dr Aaron Motsoaledi, on the 3rd of June 2010. It is located at the Sefako Makgatho Health Sciences University (SMU) where there is wide spectrum of qualified specialists in health who have varying degrees of competence in research and clinical work. The SMU is attached to Dr George Mukhari Academic Hospital, a 1400 bed tertiary hospital a tertiary hospital used for the training of health professionals.

Medical Research Council/Uganda Virus Research Institute

The proposed trial will be conducted within the Entebbe Mother and Baby Study (EMaBS) clinic in collaboration with the Entebbe Hospital located within the same environs. The EMaBS birth cohort was established in 2002 to investigate effects of helminths and their treatment on immune responses to vaccines and on susceptibility to infectious and allergy-related diseases. EMaBS is under the Immunomodulation and Vaccines (IVac) programme of the MRC/UVRI Uganda Research Unit. They have a long-standing interest in improving the understanding BCG immunization in tropical settings and have previously and currently carried out several studies on BCG. These include investigating the impact of maternal worm infections on the infant immune response to BCG (8), and the effects of maternal latent tuberculosis infection on the response to BCG and they have compared the immunogenicity of different BCG strains and examined the non-specific benefits of BCG immunization.