The Respiratory and Meningeal Pathogens Research Unit (RMPRU) is one of the involved clinical sites in the ongoing phase II VPM1002 infant trial. They have excelled in contributing to the phase II trial. The site is under the Directorship of Professor Shabir A Madhi and has conducted pivotal trials on pneumococcal conjugate vaccine, rotavirus vaccine, maternal influenza vaccination and isoniazid prophylaxis in African HIV- exposed and HIV- unexposed children over the past 21 years.