#priMe infants to stop TB

Tuberculosis (TB) is one of the top 10 causes of death worldwide. An estimated 10 million people fell ill with TB in 2018 with approximately 1.5 million dying from the disease. In children, BCG vaccination can protect against, or at least ameliorate, severe forms of systemic TB, particularly TB meningitis. Ultimately, to interrupt transmission of the disease, highly contagious pulmonary forms of TB also need to be targeted by vaccination. The priMe project evaluates the efficacy and safety of a new vaccine candidate against TB.

About priMe

In 1993, the World Health Organization (WHO) declared tuberculosis (TB) a global emergency. Approx. 1.7 billion people are infected and 10 million people are estimated to have fallen ill with TB in 2017. In the same year approx. 1.5 million died because of TB; among them 205,000 children (aged 0-14 years). South Africa and other Sub-Saharan countries belong to the group of “high-burden” TB countries with an estimated total incidence of 301,000 TB cases in 2018 in South Africa alone.

In children BCG can protect against, or at least ameliorate, severe forms of systemic TB, particularly TB meningitis.

VPM1002 is an innovative live vaccine against TB, based on the well-known Mycobacterium bovis (M. bovis) Bacille Calmette-Guérin (BCG) strain which has been administered approximately 4 billion times worldwide.

The genetic modifications of VPM1002, namely introduction of listeriolysin while simultaneously deleting the gene for urease C in the BCG genome, are aiming for better recognition by the host immune system.

News and Press

15.02.2019

The priMe project kick-off meeting took place from 28-29 November 2018 in Johannesburg, South Africa.

02.12.2019

The priMe Investigator meeting has taken place from 27-28th of November 2019 in Dar es Salaam, Tanzania.

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